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November 8, 2022Russian Journal of Pediatric Hematology and OncologyOpen Access

Acute lymphoblastic leukemia in children with Down syndrome: comparative analysis of treatment results according to ALL-MB 2008 and ALL-MB 2015 protocols

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Authors

РСР. Н. СупрунYRYu. V. RumyantsevaОБО. И. Быданов

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Overview

Randomized trial compares treatment outcomes in children with Down syndrome and acute lymphoblastic leukemia, indicating improved results with ALL-MB 2015 protocols.

Key Points

  • The study aims to compare treatment outcomes for children with Down syndrome and acute lymphoblastic leukemia (DS-ALL) receiving ALL-MB 2008 versus ALL-MB 2015 protocols.
  • Analysis included primary ALL patients aged 1 to 18 years from Russian and Belarusian clinics, from January 2008 to December 2020.
  • Matched-pair method formed a comparison group of non-DS-ALL patients for result analysis.
  • Kaplan-Meier method calculated survival rates; toxicity and clinical-genetic parameters evaluated with nonparametric statistical methods.
  • Event-free survival for DS-ALL was 61% with ALL-MB 2008 versus 85% in non-DS-ALL (p=0.001).
  • Overall survival for DS-ALL was 70% with ALL-MB 2008 versus 88% in non-DS-ALL (p<0.001).
  • Treatment under ALL-MB 2015 improved continuous complete remission to 75% for DS-ALL compared to 57% with ALL-MB 2008 (p<0.001).

Cite This Study

Супрун et al. (2022) studied this question.

synapsesocial.com/papers/6a219b494f27a676ef8b99cahttps://doi.org/10.21682/2311-1267-2022-9-3-12-31
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