Evaluation of Cardioprotective Activity of Magnolia officinalis Bark Extract against Doxorubicin Induced Toxicity in Mice

Honokiol is a lignan extracted from Magnolia officinalis, a species of Magnolia commonly found in Japan and is used as conventional drugs throughout Asia. Honokiol shows various types of pharmacological actions such as antidepressant, antimicrobial, anti-tumorigenic, anxiolytic, antithrombotic, analgesic, antispasmodic, neuroprotective and other actions. This study investigated the cardioprotective effects of Magnolia officinalis bark extract in C57 mice. The extract's ability to protect against doxorubicin (3mg/kg, i.p.)-induced cardiotoxicity was evaluated. Body weight, heart weight index, LDH, and CK-MB levels were measured as markers of Cardio protection. Histopathological analysis of heart tissues was also performed. The Magnolia officinalis extract contained various bioactive compounds, including cardiac glycosides, carbohydrates, proteins, alkaloids, glycosides, saponins, and phenols. The extract effectively protected the hearts of mice from doxorubicin-induced cardiotoxicity. Histopathological examinations supported the biochemical findings. The extract's cardioprotective action is likely attributed to its antioxidant properties. The Magnolia officinalis bark extract possesses cardioprotective activity when tested in C57 mice.