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September 28, 2025

Photoaging: molecular mechanisms, clinical impact, and treatment strategies

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Authors

MSMárcia Nayane Da SilvaUniversidad MarianaJDJhonathan DuarteUniversidad MarianaLTLuciana Daniela Garlisi ToralesUniversidad Columbia del Paraguay

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Implication

Narrative review highlights the clinical impact of UV radiation on skin aging and therapeutic options.

Key Points

  • Photoaging leads to significant skin changes, including wrinkles and increased cancer risk due to UV exposure.
  • Oxidative stress from UV radiation elevates reactive oxygen species and activates inflammatory pathways, worsening skin health.
  • Therapies such as topical retinoids and antioxidants aim to mitigate effects of photoaging and promote skin restoration.
  • Advanced treatment delivery methods like nanoparticles could enhance the effectiveness of existing therapeutic strategies.

Cite This Study

Silva et al. (2025) studied this question.

synapsesocial.com/papers/68d9052141e1c178a14f52a0https://doi.org/10.56294/evk2025251
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sunscreen and Prevention of Skin Aging2013 · 197 citations
  2. 2Photoaging and Topical Tretinoin1997 · 95 citations
  3. 3Topical Vitamin C2005 · 188 citations
  4. 4Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation2006 · 684 citations