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September 28, 2025International Endodontic JournalOpen Access

Biological Advantages of Calcium Hypochlorite Solution Over Sodium Hypochlorite for Regenerative Endodontic Procedures: An Ex Vivo and In Vitro Study on Human Apical Papilla

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Authors

HCHernán Coaguila‐LlerenaEFEduardo de Medeiros FerrazBRBarbara ROMA

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Overview

Ex vivo and in vitro evidence shows calcium hypochlorite has better cell viability and osteogenic differentiation than sodium hypochlorite.

Key Points

  • Calcium hypochlorite reduced cell and matrix damage compared to sodium hypochlorite, showing less structural impact.
  • In vitro results revealed calcium hypochlorite enhanced cell proliferation significantly while reducing chemotaxis.
  • Both calcium hypochlorite and EDTA promoted higher mineralised nodule formation than other tested solutions.
  • The findings suggest that calcium hypochlorite may enhance outcomes in regenerative endodontic procedures.

Cite This Study

Coaguila‐Llerena et al. (2025) studied this question.

synapsesocial.com/papers/68d9052541e1c178a14f55bchttps://doi.org/10.1111/iej.70038
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of various irrigation methods on the removal of calcium hydroxide from root canals: A study using confocal microscopy2026
  2. 2Effect of sodium hypochlorite and calcium hypochlorite on the apical sealing ability of endodontic sealers2024 · 2 citations
  3. 3Randomised Controlled Trial on the Additive Effect Between Calcium Hydroxide and Sodium Hypochlorite in an Inter‐Visit Root Canal Dressing2025
  4. 4Cytotoxic Effect of Two Different Concentrations of Sodium Hypochlorite: An In-Vitro Study2024 · 3 citations
  5. 5Cytotoxic effect of 1% and 3% Sodium hypochlorite as irrigation agent in primary teeth on human red blood cells: an in vitro study2024 · 2 citations