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December 4, 2025International Endodontic JournalOpen Access

Randomised Controlled Trial on the Additive Effect Between Calcium Hydroxide and Sodium Hypochlorite in an Inter‐Visit Root Canal Dressing

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Authors

VBVasudev BallalNRNamith RaiPSPadmaja A. Shenoy

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Overview

Randomised controlled trial shows significant antimicrobial effect of sodium hypochlorite in root canals with pulpal necrosis, suggesting improved treatment outcomes.

Key Points

  • Combining sodium hypochlorite with calcium hydroxide dressing significantly reduced microbial load in root canals.
  • After treatment, 40% of canals dressed with sodium hypochlorite showed no microbial growth compared to 6% with saline.
  • The study utilized a randomised controlled trial design, assessing microbial counts and inflammatory markers across treatment groups.
  • Suggestions for clinical practice include using sodium hypochlorite to enhance antimicrobial effectiveness in root canal treatments.

Cite This Study

Ballal et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca290dhttps://doi.org/10.1111/iej.70078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Randomised Controlled Trial on the Additive Effect Between Calcium Hydroxide and Sodium Hypochlorite in an Inter-Visit Root Canal Dressing2025
  2. 2Effectiveness of various irrigation methods on the removal of calcium hydroxide from root canals: A study using confocal microscopy2026
  3. 3Biological Advantages of Calcium Hypochlorite Solution Over Sodium Hypochlorite for Regenerative Endodontic Procedures: An Ex Vivo and In Vitro Study on Human Apical Papilla2025
  4. 4Effectiveness of mechanical vs. chemomechanical methods in removing intracanal calcium hydroxide medication: a randomised trial2024 · 1 citations
  5. 5Molecular analysis of intracanal microbial reduction to compare the effectiveness of glycyrrhizin and calcium hydroxide as intracanal medications: a randomised controlled trial2026