What question did this study set out to answer?

This research aims to evaluate and compare the antibacterial effectiveness of glycyrrhizin and calcium hydroxide as intracanal medications in endodontic treatment.

March 14, 2026BMC Oral HealthOpen Access

Molecular analysis of intracanal microbial reduction to compare the effectiveness of glycyrrhizin and calcium hydroxide as intracanal medications: a randomised controlled trial

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Authors

OKOmar Talib KhaleefahMansoura University AEAhmed M. El-BazQassim University MGMohamed Ahmed GomaaMansoura University

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Implication

A randomised controlled trial compares glycyrrhizin and calcium hydroxide for their effectiveness in reducing bacteria in root canals, suggesting glycyrrhizin's superiority.

Key Points

This research aims to evaluate and compare the antibacterial effectiveness of glycyrrhizin and calcium hydroxide as intracanal medications in endodontic treatment.
Double-blind randomized controlled trial with 28 patients diagnosed with pulp necrosis and asymptomatic apical periodontitis.
Patients were randomly assigned to receive either glycyrrhizin or calcium hydroxide as intracanal medicaments.
Bacterial samples were collected before treatment and after the placement of medicaments for molecular analysis using real-time PCR.
Statistical analysis employed mixed-effects two-way repeated-measures models and the Mann–Whitney U test.
Significant reductions in log-transformed bacterial RNA were observed in the glycyrrhizin group compared to calcium hydroxide (p < 0.0001).
A greater reduction in log-transformed bacterial DNA was also confirmed in the glycyrrhizin group (p = 0.0004).
Both glycyrrhizin and calcium hydroxide effectively reduced bacteria, but glycyrrhizin demonstrated superior antibacterial activity.

Cite This Study

Khaleefah et al. (2026) studied this question.

synapsesocial.com/papers/69b4fb1bb39f7826a300bab3 https://doi.org/10.1186/s12903-026-07906-6

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Implication

A randomised controlled trial compares glycyrrhizin and calcium hydroxide for their effectiveness in reducing bacteria in root canals, suggesting glycyrrhizin's superiority.

Molecular analysis of intracanal microbial reduction to compare the effectiveness of glycyrrhizin and calcium hydroxide as intracanal medications: a randomised controlled trial

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Implication

Key Points

Cite This Study

Molecular analysis of intracanal microbial reduction to compare the effectiveness of glycyrrhizin and calcium hydroxide as intracanal medications: a randomised controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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