September 28, 2025Global Spine JournalOpen Access

Development and Validation of a Predictive Model and Web-Based Calculator for Cage Subsidence After Midline Lumbar Interbody Fusion (MIDLIF) Surgery

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The prediction model demonstrated strong discriminative ability with AUCs of 0.924 in the training set and 0.884 in internal validation.
Independent predictors of cage subsidence included elevated BMI, higher endplate bone quality scores, and lower Hounsfield unit values.
Inter-rater reliability of endplate bone quality scoring was high, indicated by ICC values above 0.9 across different cohorts.
An online risk calculator was developed from the nomogram to assist clinicians in predicting cage subsidence risk in MIDLIF patients.

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Retrospective study developed a predictive model for cage subsidence in MIDLIF patients, suggesting clinical applicability.

Zhao et al. (2025) studied this question.

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