What type of study is this?

This is a Systematic Review study (also classified as: Meta-Analysis).

September 28, 2025Frontiers in PediatricsOpen Access

Efficacy of glyburide vs. metformin in preventing neonatal birth obesity in pregnancies complicated by gestational diabetes mellitus: a systematic review and meta-analysis

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Meta-analysis shows glyburide increases risk of macrosomia, while metformin reduces it in GDM pregnancies.

Overall risk of macrosomia did not differ between oral medications and insulin, indicating efficacy concerns.
Glyburide was linked to a higher risk of macrosomia with an odds ratio of 1.3806, highlighting safety concerns.
Metformin significantly reduced the risk of macrosomia and infant birth weight in patients with GDM.
This analysis emphasizes personalized treatment strategies in managing gestational diabetes and its risks.

Jiang et al. (2025) studied this question.

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