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September 28, 2025International Journal of Molecular SciencesOpen Access

Long-Term Effects of Stress During Adolescence on the Sex-Dependent Responses of Thyroid Axis and Target Tissues to Exercise in Male and Female Wistar Rats

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Authors

MDMarco Parra-Montes deLJLorraine Jaimes-HoyKGKaren Garduño

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Overview

Chronic variable stress alters hypothalamic–pituitary–thyroid axis responses and exercise effects in Wistar rats, suggesting sex differentiation.

Key Points

  • Adolescent stress modifies metabolic responses to exercise in a sex-dependent manner, impacting both males and females.
  • Corticosterone levels increased by 1.5× in males after chronic variable stress, revealing hormonal changes influenced by exercise.
  • Exercise elevated several thyroid hormone-related parameters in both sexes, but chronic stress dampened these responses except for specific adaptations.
  • Findings point to significant implications for understanding how early stress affects later physiological adaptations to exercise.

Cite This Study

de et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0141e1c178a14f5e7dhttps://doi.org/10.3390/ijms26199425
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thyroid Hormone Activation in Vascular Smooth Muscle Cells Is Negatively Regulated by Glucocorticoid2009 · 22 citations
  2. 2Minor perturbations of thyroid homeostasis and major cardiovascular endpoints—Physiological mechanisms and clinical evidence2022 · 36 citations
  3. 3Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats2008 · 647 citations