Population
Male Wistar rats (adolescent and adult)
Design
Preclinical
Follow-up
Longitudinally into adulthood
Key result
Chronic variable stress increased mean arterial pressure and heart rate in both adolescent and adult rats, while repeated restraint stress increased blood pressure selectively in adults.
Authors
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Hypothesis-generating for age- and stressor-specific BP responses in rats; leaves open human translational relevance.
Stress exposure during adolescence causes somatic and neuroendocrine changes and age-specific cardiovascular/autonomic alterations, but these have minimal consequences in adulthood.
Duarte et al. (2015) studied Stress. Repeated restraint stress (RRS) or chronic variable stress (CVS) vs. Adult rats / different stress regimens was evaluated on Mean arterial pressure and heart rate. Chronic variable stress increased mean arterial pressure and heart rate in both adolescent and adult rats, while repeated restraint stress increased blood pressure selectively in adults.
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