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This is a Cross-Sectional Study study.

September 28, 2025Journal of Antimicrobial ChemotherapyOpen Access

Comparative evaluation of disc diffusion and broth microdilution methods for aztreonam/avibactam susceptibility testing in Enterobacterales

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Authors

IBIoannis BaltasUniversity College Hospital DTDeny TsakriNational and Kapodistrian University of Athens SVS. VourliNational Centre of Scientific Research "Demokritos"

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Implication

Study compares disc diffusion and broth microdilution methods for testing aztreonam/avibactam in carbapenem-resistant Enterobacterales, indicating differing susceptibility results.

Key Points

Using broth microdilution, 94.2% of carbapenem-resistant Enterobacterales isolates were found susceptible to aztreonam/avibactam, contrasting with 66.9% by disc diffusion.
Categorical agreement between testing methods was 72.7%, but a breakpoint of 22 mm improved agreement to 99.6%, reducing major errors.
Most tested isolates were Klebsiella pneumoniae, with a high prevalence of carbapenemase production, including KPC and MBL types.
The study highlights significant discrepancies in susceptibility results between broth microdilution and disc diffusion methods for this antibiotic combination.

Cite This Study

Baltas et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0141e1c178a14f5f9a https://doi.org/10.1093/jac/dkaf361

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Implication

Study compares disc diffusion and broth microdilution methods for testing aztreonam/avibactam in carbapenem-resistant Enterobacterales, indicating differing susceptibility results.

Comparative evaluation of disc diffusion and broth microdilution methods for aztreonam/avibactam susceptibility testing in Enterobacterales

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparative evaluation of disc diffusion and broth microdilution methods for aztreonam/avibactam susceptibility testing in Enterobacterales

Discussion

Member takes

Implication

Key Points

Cite This Study

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