What question did this study set out to answer?

This study aims to compare the performance of various laboratory-developed tests for detecting susceptibility to aztreonam plus ceftazidime-avibactam in MBL-producing Enterobacterales.

May 24, 2026Journal of Clinical MicrobiologyOpen Access

Comparison of laboratory-developed methods for aztreonam plus ceftazidime-avibactam antimicrobial susceptibility testing for metallo-beta-lactamase-producing Enterobacterales

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Authors

ABAmelia BhatnagarCenters for Disease Control and Prevention HHHarley HarrisJohns Hopkins University EJEmily JacobsJohns Hopkins University

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Implication

Randomized trial compares aztreonam plus ceftazidime-avibactam susceptibility testing in Enterobacterales, highlighting method variability.

Key Points

This study aims to compare the performance of various laboratory-developed tests for detecting susceptibility to aztreonam plus ceftazidime-avibactam in MBL-producing Enterobacterales.
Evaluated 102 MBL-producing Enterobacterales isolates at CDC and JHU.
Compared four phenotypic methods: BDE, DS, SS, and strip-disk against rBMD.
Assessed accuracy and reproducibility for each method.
BDE achieved 92.2% accuracy at CDC and 96.1% at JHU, exceeding acceptable performance.
DS exhibited the lowest accuracy, ranging from 51% to 76.5% at CDC and 31% to 49% at JHU.
SS showed variability with essential agreement from 46.1% to 86.3%.

Cite This Study

Bhatnagar et al. (2026) studied this question.

synapsesocial.com/papers/6a12968148a0ea1665673616 https://doi.org/10.1128/jcm.01800-25

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Implication

Randomized trial compares aztreonam plus ceftazidime-avibactam susceptibility testing in Enterobacterales, highlighting method variability.

Comparison of laboratory-developed methods for aztreonam plus ceftazidime-avibactam antimicrobial susceptibility testing for metallo-beta-lactamase-producing Enterobacterales

Discussion

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Implication

Key Points

Cite This Study

Comparison of laboratory-developed methods for aztreonam plus ceftazidime-avibactam antimicrobial susceptibility testing for metallo-beta-lactamase-producing Enterobacterales

Discussion

Member takes

Implication

Key Points

Cite This Study

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