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Analysis reveals enhanced efficiency and compatibility in coupling tetrazines with arylboronic acids, suggesting new pathways for bioorthogonal applications.
An improved catalyst system, PdI2/DiPPF, is described for the silver-mediated Liebeskind-Srogl coupling of thioalkyltetrazines with arylboronic and heteroarylboronic acids. The methodology advances the synthesis of functionalized tetrazines, offering greater efficiency, broader compatibility, and practical utility for accessing tool molecules for bioorthogonal chemistry applications.
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Lambert et al. (2025) studied this question.
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