Obesity hypoventilation syndrome in the era of GLP-1 receptor agonists and SGLT2 inhibitors: limitations of serum bicarbonate as a screening tool

Journal Article Accepted manuscript Obesity hypoventilation syndrome in the era of GLP-1 receptor agonists and SGLT2 inhibitors: limitations of serum bicarbonate as a screening tool Get access Ari Manuel, Ari Manuel University of Liverpool NHS Trust, Aintree Hospital, Longmoor Lane, Liverpool, United Kingdom L9 7ALUniversity of Liverpool, Liverpool, United Kingdom Corresponding author. Ari Manuel, Consultant in Respiratory and Sleep Medicine, University of Liverpool NHS Trust, Aintree Hospital, Longmoor Lane, Liverpool, UK L9 7AL. Email: [email protected] Search for other works by this author on: Oxford Academic Google Scholar Swapna Mandal, Swapna Mandal Royal Free London NHS Foundation Trust, Sleep and Ventilation, London, United Kingdom Search for other works by this author on: Oxford Academic Google Scholar Jean-Louis Pépin, Jean-Louis Pépin University Grenoble Alpes, HP2 Laboratory, INSERM U1300, CS10217, Grenoble, France 38000 https://orcid.org/0000-0003-3832-2358 Search for other works by this author on: Oxford Academic Google Scholar Amanda Piper, Amanda Piper Royal Prince Alfred Hospital, Respiratory and Sleep, Sydney, NSW, AustraliaWoolcock Institute of Medical Research, Glebe, NSW, Australia 2037 Search for other works by this author on: Oxford Academic Google Scholar Nicholas Hart, Nicholas Hart Guy's and St Thomas' Hospitals NHS Trust, London, United Kingdom Search for other works by this author on: Oxford Academic Google Scholar Babak Mokhlesi Babak Mokhlesi Rush University Medical Center, Section of Pulmonary, Critical Care and Sleep Medicine, 1750 W. Harrison Street, Jelke 293, Chicago, IL 60612-3833, United States https://orcid.org/0000-0001-8135-5433 Search for other works by this author on: Oxford Academic Google Scholar Sleep, zsaf297, https://doi.org/10.1093/sleep/zsaf297 Published: 27 September 2025 Article history Received: 04 September 2025 Accepted: 14 September 2025 Published: 27 September 2025