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September 28, 2025ChemistrySelect

Cyclodextrin‐Assisted Synthesis, Statistical Optimization, Antibacterial Evaluation, DFT, and Molecular Docking of Quinolone–1,2,3‐Triazole Hybrids

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Triazole derivatives exhibited enhanced antibacterial activity, with MICs as low as 0.31 µg/mL, especially against S. pneumoniae.
Molecular docking showed strong binding of triazole derivatives to Streptococcus pneumoniae PBPs, with binding energies up to –8.15 kcal/mol.
The cycloaddition mechanism was supported by DFT and Fukui analyses, confirming the synthesis process.
Statistical optimization confirmed ideal conditions for the synthesis using β-cyclodextrin and specific reaction times.

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Implication

Synthesis of quinolone-triazole hybrids improved antibacterial activity against Streptococcus pneumoniae, indicating potential as antimicrobial agents.

Cite This Study

Moussaoui et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0f41e1c178a14f6a18 https://doi.org/10.1002/slct.202502783

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Implication

Synthesis of quinolone-triazole hybrids improved antibacterial activity against Streptococcus pneumoniae, indicating potential as antimicrobial agents.

Cyclodextrin‐Assisted Synthesis, Statistical Optimization, Antibacterial Evaluation, DFT, and Molecular Docking of Quinolone–1,2,3‐Triazole Hybrids

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Implication

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Cyclodextrin‐Assisted Synthesis, Statistical Optimization, Antibacterial Evaluation, DFT, and Molecular Docking of Quinolone–1,2,3‐Triazole Hybrids

Key Points

Discussion

Implication

Cite This Study

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