This case highlights the management of a gastric gists with tumor rupture in a young patient, suggesting the need for individualized therapy and effective follow-up.
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms, especially in pediatric patients, often presenting with distinct clinical and molecular characteristics. This case report describes a 12-year-old girl with a large gastric GIST complicated by tumor rupture and hemoperitoneum. Initial treatment with imatinib was followed by emergent surgical intervention due to tumor bleeding. Histopathology confirmed an epithelioid-type GIST, necessitating continued imatinib therapy. Pediatric GISTs demonstrate an indolent but unpredictable course, requiring a multidisciplinary approach. Despite their aggressive nature, pediatric cases show better survival outcomes than adults. This case underscores the importance of timely intervention, individualized therapy, and long-term follow-up to improve prognosis in children with GISTs.
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Alkhatib et al. (2025) studied this question.
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