The Effect of Natural Osteoprotectors and Antioxidants on Calcium Homeostasis, Lipid Spectrum, and Structural and Functional Parameters of the Vascular Wall in Women With Hypertension of Reproductive Age and Menopause

The article notes the insufficient effectiveness of dual antihypertensive therapy (Perindopril and Amlodipine) in relation to lipid and calcium homeostasis, as well as peripheral hemodynamics and vascular wall rigidity in women with grade 1–2 hypertension and low cardiovascular risk. The article assesses the effect of the natural osteoprotector Osteo-Vit D3 and the antioxidant Dihydroquercetin Plus on the main indicators of the lipid spectrum, phosphorus-calcium metabolism and structural and functional parameters of the vascular wall in women of reproductive age and during menopause suffering from hypertension. It is shown that the addition of these drugs to standard antihypertensive therapy contributes to a significant improvement in the lipid profile in both study groups: a decrease in total cholesterol, low-density lipoproteins and triglycerides. In groups of women of reproductive age, statistically significant decrease in calcium, increase in magnesium and vitamin D were established, in the subgroup taking only Osteo-Vit D3 in addition to antihypertensive therapy - decrease in alkaline phosphatase level. In groups of women over 45 years old, similar dynamics were recorded in relation to vitamin D and magnesium, decrease in calcium level, increase in alkaline phosphatase was observed. In the subgroup taking Osteo-Vit D3 and Dihydroquercetin Plus along with antihypertensive therapy, decrease in inorganic phosphorus was noted. Significant effect of Dihydroquercetin Plus on the structural and functional properties of blood vessels in women with arterial hypertension during menopause is emphasized. The authors suggest that the observed effects may be associated with the ability of the studied drugs to eliminate hormonal, metabolic and mineral imbalances and recommend their use for early prevention of cardiovascular diseases in women of reproductive age and for therapeutic purposes during menopause.