Focused ultrasound-mediated microbubble cavitation improves radiopharmaceutical access in immune-resistant lung carcinoma, suggesting better treatment efficiency.
Background: Immune-resistant lung carcinoma poses a major hurdle for effective cancer treatment, largely due to its dense tumor microenvironment (TME) and the challenges of drug penetration. To boost the effectiveness of radiopharmaceuticals in this intricate TME, focused ultrasound-mediated microbubble cavitation (FUS-MMC) needs to enhance their accessibility. Current delivery methods often fall short, suffering from limited vascular permeability and insufficient tumor uptake. This results in less effective treatments and increased off-target toxicity.
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Yu et al. (2025) studied this question.
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