Combining radiation therapy with microbubbles: An emerging and promising approach to cancer treatment

• Microbubbles, loaded with chemotherapeutic agents enable precise drug release at the tumor site, improving drug accumulation and minimizing degradation • Targeted drug delivery methods, such as ultrasound-stimulated microbubbles (USMB), offer a promising solution by enhancing drug delivery to tumors while minimizing systemic side effects. • USMB, when combined with concentional therapy, showed significant efficacy in hindering tumorigenesis process • Gemcitabine-conjugated microbubbles, suggest the superiority of drug-loaded microbubble approaches over co-administration methods