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September 28, 2025

Biocompatibility and bioactivity of bioceramic endodontic sealer: NeoSealer Flo.

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Authors

ESEvelin Carine Alves SilvaJPJéssica Arielli PradelliGSGuilherme Ferreira da Silva

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Overview

Laboratory evaluation of NeoSealer Flo indicates lower biocompatibility but notable bioactivity in connective tissue.

Key Points

  • NeoSealer Flo exhibited a higher number of inflammatory cells compared to Bio-C Sealer and AH Plus, marking reduced biocompatibility.
  • At 60 days, NeoSealer Flo showed moderate inflammation and better fibrous tissue response over time, alongside collagen increase.
  • Analysis involved tissue response evaluation in rat models across several time points using two-way ANOVA and other statistical tests.
  • Results imply that although NeoSealer Flo has lower biocompatibility, its bioactivity in connective tissue may have therapeutic potential.

Cite This Study

Silva et al. (2025) studied this question.

synapsesocial.com/papers/68d913ab4ddcf71ba560bc95https://doi.org/10.1590/1678-7757-2025-0284
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Also Consider

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