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September 28, 2025Anticancer Research

Matrix Metalloproteinase-1 as an Independent Prognostic Biomarker in Epithelial Ovarian Carcinoma

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Authors

KHKohei HikinoTottori University HospitalHKHiroaki KomatsuSapporo Medical UniversityYKYasuhiro KazukiNational Institutes of Natural Sciences

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Implication

Analysis reveals elevated MMP-1 levels as a poor prognostic factor in ovarian cancer, suggesting improved prediction when combined with CA125.

Key Points

  • Elevated serum MMP-1 levels correlate with poorer overall survival in ovarian cancer patients.
  • In this analysis, high MMP-1 levels predict reduced survival rates, with focus on 74 patients sampled.
  • Preoperative assessment involved measuring serum MMP-1 and utilizing tumor tissue expression evaluations.
  • Combining MMP-1 with CA125 levels may enhance prognostic accuracy for ovarian cancer patients.

Cite This Study

Hikino et al. (2025) studied this question.

synapsesocial.com/papers/68d9393b00263befa47b3013https://doi.org/10.21873/anticanres.17795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer2026
  2. 2Matrix Metalloproteinase 1 Acts as an Independent Prognostic Biomarker Correlated with Immune Infiltration in Breast Cancer2024
  3. 3MMP1 is a promising prognostic, therapeutic and immunological biomarker for pancreatic cancer: evidence from bioinformatics analysis and biological experiments2026
  4. 4AICD-associated MMP1 in ovarian cancer: Prognostic, spatial, and functional evidence2026
  5. 5Plasma Levels of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-1 Correlate With Disease Stage and Survival in Colorectal Cancer Patients2005 · 78 citations