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September 28, 2025Anticancer Research

Exploring the Clinical Significance of Circulating H19 lncRNA and IGF-2 mRNA in Colorectal Carcinoma

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Authors

MÇMehmet ÇiftçiEÖEmre ÖzgürCKCemil Burak Kulle

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Overview

This study demonstrates higher levels of H19 lncRNA and IGF-2 mRNA in colorectal carcinoma patients, suggesting their potential role as cancer biomarkers.

Key Points

  • H19 lncRNA and IGF-2 mRNA levels are significantly elevated in colorectal carcinoma patients compared to controls.
  • CRC patients had median H19 lncRNA values of 912, significantly higher than 97 in polyp controls and 262 in non-polyp controls.
  • Differences in plasma IGF-2 mRNA levels followed a similar pattern, highlighting their potential as cancer biomarkers.
  • H19 lncRNA levels correlate with lymph node metastases, indicating its role in cancer progression.

Cite This Study

Çiftçi et al. (2025) studied this question.

synapsesocial.com/papers/68d9393b00263befa47b302bhttps://doi.org/10.21873/anticanres.17775
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The expression profiling of serum circPHLPP2 and LncRNA ILF3 in colorectal cancer patients2026
  2. 2LINC01132 and LINC02542 modulate the PIK3/ACT signaling pathway in colorectal cancer patients through regulation of IGF2: a systems biology-based biomarker discovery2024
  3. 3LINC01132 and LINC02542 modulate the PIK3/ACT signaling pathway in breast cancer patients through regulation of IGF2: a systems biology-based biomarker discovery2024
  4. 4Small-nucleolar RNA host gene3 (SNHG3) and leukemia-associated non-coding IGF1R activator RNA 1 (LUNAR1) correlated with CRC patients’ clinical features: a step-toward ncRNA-precision2026
  5. 5An exploratory study of circulating cell-free mRNAs across colorectal cancer stages2026