Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026iScienceOpen Access

An exploratory study of circulating cell-free mRNAs across colorectal cancer stages

View Full Paper
Ask AI
Bookmark
Share

Authors

TMThibault MazardMGMarie GrosgeorgesLVLaura Veyrié

Discussion

Loading...

Member takes

Overview

Exploratory study evaluates circulating mRNAs as biomarkers for colorectal cancer stages, indicating diagnostic potential for early detection.

Key Points

  • This study aims to evaluate circulating mRNAs as potential biomarkers for different stages of colorectal cancer (CRC).
  • Evaluated plasma levels of specific mRNAs in CRC patients (n=178) and healthy individuals (n=171).
  • Developed a composite index, I-BTC, using logistic regression of mRNA levels.
  • Assessed mRNA levels across CRC stages I–IV and compared with healthy individuals.
  • B2M, TIMP-1, CLU, and S100A9 mRNA levels were significantly elevated in CRC patients compared to healthy individuals.
  • The composite index I-BTC improved discrimination between healthy individuals and CRC patients, particularly at stage I (p=0.001).
  • Stronger significance was observed in later stages, with p-values ≤ 0.0001 for mRNA levels.

Cite This Study

Mazard et al. (2026) studied this question.

synapsesocial.com/papers/6a362d9ddb0793dc1a535ce7https://doi.org/10.1016/j.isci.2026.116398
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CEMIP1 and TACSTD2 as circulating mRNA biomarkers for early detection and tumor burden assessment in colorectal neoplasia2026
  2. 2Plasma matrix metalloproteinases 7 and 8 and tissue inhibitor of metalloproteinases 1 as prognostic biomarkers in colorectal cancer2025 · 1 citations
  3. 3Paradoxical prognosis of extracellular vesicle-derived miR-4435 expression in advanced colorectal cancer2026
  4. 4Integrated Analysis of Multiple Databases Identifies Tissue Inhibitor of Metalloproteinase 1 Expression and Its Association with the Immune Microenvironment in Colorectal Cancer2026
  5. 5Blood miRNAs miR-549a, miR-552, and miR-592 serve as potential disease-specific panels to diagnose colorectal cancer2024 · 2 citations