Key result
Elevated plasma levels of MMP-7, MMP-8, and TIMP-1 above cut-offs were significantly associated with overall survival in colorectal cancer patients (HR 4.57, 2.03, and 7.64, respectively).
Why the study?
Studies investigating circulating MMPs and TIMPs as cancer biomarkers have yielded confounding results, potentially due to preanalytical issues like using serum instead of plasma.
Are plasma levels of selected MMPs and TIMPs associated with the diagnosis and prognosis of colorectal cancer?
Comparison
Colorectal cancer patients vs healthy controls, and early vs advanced colorectal cancer
Design
Case-control study
Authors
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Plasma MMP-7, MMP-8, and TIMP-1 are potential prognostic biomarkers for colorectal cancer, though they lack diagnostic utility.
Case-Control (n=216)
No
Are plasma levels of selected MMPs and TIMPs associated with the diagnosis and prognosis of colorectal cancer?
Effect estimate: HR 4.57, 2.03, and 7.64
Plasma MMP-7, MMP-8, and TIMP-1 are potential prognostic biomarkers for colorectal cancer, though they lack diagnostic utility.
Karlíková et al. (2025) conducted a case-control in Colorectal cancer (n=216). Elevated plasma MMP-7, MMP-8, and TIMP-1 vs. Levels below cut-offs / healthy controls was evaluated on Overall survival (HR 4.57, 2.03, and 7.64). Elevated plasma levels of MMP-7, MMP-8, and TIMP-1 above cut-offs were significantly associated with overall survival in colorectal cancer patients (HR 4.57, 2.03, and 7.64, respectively).
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