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May 17, 2026Current Issues in Molecular BiologyOpen Access

Potential Prognostic and Metastatic Implications of MACC1 and MMP8 in Colorectal Cancer

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Authors

HSHilal Oğuz SoydinçIstanbul UniversitySŞSena ŞenIstanbul UniversityMSMurat SerilmezIstanbul University

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Implication

Randomized trial investigates MACC1 and MMP8 for prognosis in colorectal cancer, suggesting limited utility.

Key Points

  • This study aims to evaluate the prognostic value of MACC1 and MMP8 expression levels in colorectal cancer.
  • Included 140 colorectal cancer patients and 48 healthy controls.
  • Measured serum levels of MACC1 and MMP8 using ELISA.
  • Analyzed associations between biomarkers and clinicopathological parameters.
  • MACC1 associated with metastasis status and tumor stage.
  • MMP8 linked to tumor localization; both show moderate diagnostic performance.
  • In multivariate analysis, tumor stage is the only consistent independent prognostic factor.

Cite This Study

Soydinç et al. (2026) studied this question.

synapsesocial.com/papers/6a095bef7880e6d24efe1cf0https://doi.org/10.3390/cimb48050496
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Also Consider

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  1. 1An algorithm-based meta-analysis of genome- and proteome-wide data identifies a combination of potential plasma biomarkers for colorectal cancer2019 · 20 citations
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