Key result
High expression of MMP19 was independently associated with a significantly shorter overall survival (HR 5.595) and disease-free survival in patients with colorectal cancer.
Why the study?
The expression of matrix metalloproteinase 19 has been demonstrated in some cancers, but its clinical significance in colorectal cancer had not been reported.
Does high MMP19 expression predict poor prognosis in patients with colorectal cancer?
Population
Patients with colorectal cancer from TCGA, GSE39582, and an in-house cohort
Comparison
High vs low MMP19 expression
Design
Multi-cohort observational validation study
Authors
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May support MMP19 for prognostic stratification in colorectal cancer; leaves open prospective validation and therapeutic implications.
Cohort (n=1,053)
Yes
Does high MMP19 expression predict poor prognosis in patients with colorectal cancer?
Hazard Ratio: 5.595 (95% CI 2.573–12.164)
Absolute Event Rate: 60% vs 90.3%
p-value: p=<0.001
High expression of MMP19 is an independent predictor of poor overall and disease-free survival in patients with colorectal cancer.
Chen et al. (2019) conducted a cohort in Colorectal cancer (n=1,053). High MMP19 expression vs. Low MMP19 expression was evaluated on Overall survival (HR 5.595, 95% CI 2.573-12.164, p=<0.001). High expression of MMP19 was independently associated with a significantly shorter overall survival (HR 5.595) and disease-free survival in patients with colorectal cancer.
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