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This is a Cohort Study study (also classified as: Experimental Study).

September 28, 2025Nature CommunicationsOpen Access

V-ATPase-dependent induction of selective autophagy

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This research uncovers how V-ATPase dysfunction triggers autophagy in follicular lymphoma, indicating novel metabolic links.

V-ATPase dysfunction activates selective autophagy, revealing a new role for this enzyme in cancer biology.
Transcriptomic and proteomic profiling discovered that tryptophan metabolism negatively regulates autophagy through two effector pathways.
The findings suggest mutations in V-ATPase genes promote autophagy, contributing to tumor survival under nutrient-rich conditions.
This study highlights an unexplored mechanism of autophagy regulation distinct from typical nutrient deprivation responses.

Huang et al. (2025) studied this question.

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