What question did this study set out to answer?

To examine the role of V-ATPase in autophagic membrane dynamics and evaluate its potential function in cargo uptake beyond organellar acidification.

May 24, 2011AutophagyOpen Access

V-ATPase engagement in autophagic processes

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Authors

DMDalibor MijaljicaLeo Pharma (Australia)MPMark PrescottAustralian Regenerative Medicine Institute RDRodney J. DevenishAustralian Regenerative Medicine Institute

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Implication

Literature review uncovers potential direct roles of V-ATPase in autophagic cargo uptake at the vacuolar membrane, highlighting mechanisms beyond organelle acidification.

Key Points

To examine the role of V-ATPase in autophagic membrane dynamics and evaluate its potential function in cargo uptake beyond organellar acidification.
Literature synthesis assessing evidence on V-ATPase proton-pumping activity and vacuolar hydrolase activation.
Conceptual evaluation of direct membrane-to-membrane contact dynamics between selective autophagic cargos and the vacuolar membrane.
Established that lumenal acidification driven by V-ATPase proton pumping is essential for triggering resident hydrolase activity to degrade autophagic cargos.
Hypothesized that autophagic mechanisms requiring direct membrane-to-membrane contacts between targeted cargos and the vacuolar membrane specifically depend on functional V-ATPase.

Cite This Study

Mijaljica et al. (2011) studied this question.

synapsesocial.com/papers/6aa7b45d5a44c3b67fae585a https://doi.org/10.4161/auto.7.6.15812

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Implication

Literature review uncovers potential direct roles of V-ATPase in autophagic cargo uptake at the vacuolar membrane, highlighting mechanisms beyond organelle acidification.

V-ATPase engagement in autophagic processes

Discussion

Member takes

Implication

Key Points

Cite This Study

V-ATPase engagement in autophagic processes

Discussion

Member takes

Implication

Key Points

Cite This Study

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