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September 28, 2025Medical Microbiology and ImmunologyOpen Access

Effect of controlled human Plasmodium falciparum infection on B cell subsets in individuals with different levels of malaria immunity

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Authors

PRPilar RequenaInstituto de Investigación Biosanitaria de GranadaGGGloria P. Gómez-PérezPharmAccess GroupMMMatthew N. McCallRadboud University Nijmegen

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Implication

This research assesses B cell changes after controlled malaria infection in individuals with varying malaria immunity, suggesting immunity influences immune response.

Key Points

  • A single malaria infection modifies frequencies of B cell subsets, especially in semi-immune individuals.
  • Increases in immature B cells and active naive B cells were noted among semi-immune subjects compared to naïve individuals.
  • Vaccination alters B cell responses, positively affecting classical MBCs and negatively impacting atypical MBCs in response to malaria exposure.
  • The sickle cell trait influences B cell frequencies during controlled malaria infections, highlighting genetic factors in immune responses.

Cite This Study

Requena et al. (2025) studied this question.

synapsesocial.com/papers/68d9393b00263befa47b3088https://doi.org/10.1007/s00430-025-00847-x
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