Experimental procedure demonstrates efficient electrophilic aromatic bromination in water, suggesting a greener approach.
Electrophilic aromatic bromination reactions are an important class of chemical transformations used to synthesize key intermediates and products. We report an experimental procedure for the bromination of 4-methylanisole using KBr and Oxone in water that can be completed in 40 min at room temperature. This procedure incorporates several principles of green chemistry, providing a safer alternative to the traditional method used for bromination of aromatic compounds. The crude reaction product was characterized using IR and 1H NMR.
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Theccanat et al. (2025) studied this question.
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