September 29, 2025

Assessment of response to total neoadjuvant therapy in carcinoma rectum: A real-world prospective observational study from eastern India.

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Authors

PMP. MukherjeeBharat Electronics (India)SBSandip Kumar BarikSiksha O Anusandhan University SMS MajumdarAll India Institute of Medical Sciences Bhubaneswar

Discussion

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Implication

Observational study reports 75% overall survival in patients undergoing total neoadjuvant therapy for rectal cancer, indicating improved treatment feasibility.

Key Points

Pathological complete response observed in 37% of patients, with R0 resection achieved in 96%.
84.4% of patients underwent definitive surgery after total neoadjuvant therapy.
The treatment was well tolerated, with 40.6% experiencing acute grade 3 or higher adverse events.
At 2 years follow-up, overall survival and progression-free survival were 75% and 59.4%, respectively.

Cite This Study

Mukherjee et al. (2025) studied this question.

synapsesocial.com/papers/68da58d1c1728099cfd10cba https://doi.org/10.4103/jcrt.jcrt_742_25

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Implication

Observational study reports 75% overall survival in patients undergoing total neoadjuvant therapy for rectal cancer, indicating improved treatment feasibility.

Assessment of response to total neoadjuvant therapy in carcinoma rectum: A real-world prospective observational study from eastern India.

Discussion

Member takes

Implication

Key Points

Cite This Study

Assessment of response to total neoadjuvant therapy in carcinoma rectum: A real-world prospective observational study from eastern India.

Discussion

Member takes

Implication

Key Points

Cite This Study

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