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September 29, 2025Cancer Research

Abstract B074: scRNA-seq from FFPE tissue resolves the tumor microenvironment of intraductal papillary mucinous neoplasms

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Authors

AFAshley A. FletcherDuke UniversityECErika J. CrosbyDuke UniversityDNDaniel P. NussbaumDuke University

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Overview

Single-cell RNA-sequencing reveals immune differences in low-grade lesions in IPMN, suggesting new diagnostic pathways.

Key Points

  • Single-cell RNA-sequencing identified immune cell variations that distinguish low-risk from high-risk IPMN lesions.
  • The study profiled 90,950 cells from FFPE tissues, highlighting the largest single-cell effort focused on IPMN.
  • Findings reveal that low-risk samples have more effector memory CD8+ T cells compared to high-risk and invasive samples.
  • Inferred cell–cell interactions showed diverse signaling strengths across various IPMN lesion types.

Cite This Study

Fletcher et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd11384https://doi.org/10.1158/1538-7445.pancreatic25-b074
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract B091: Spatial Transcriptomics Unveils Intraductal Papillary Mucinous Neoplasm Heterogeneity: From Novel Clusters to Immune Dynamics2024
  2. 2Abstract PR-14: Meta-analysis of spatial transcriptomics data from pancreatic cancer precursors proposes a common molecular framework for PanIN and IPMN2024
  3. 3Abstract A009: Characterizing the pre-metastatic liver in PDAC patients using scRNA-seq of FFPE tissue2025
  4. 4Abstract B117: Intraductal Papillary Mucinous Neoplasm Cellular Plasticity Linked with Repeat Element Dysregulation2025
  5. 5Abstract B067: Novel Biological and Radiological Markers for Predicting Malignant Progression in IPMN: A Prospective Study2025