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September 29, 2025Trends in Sciences

Ultrasound-Assisted Extraction of Flavonoids from Erythrina crista-galli Twigs Using Natural Deep Eutectic Solvents: Process Optimization and Antioxidant Evaluation

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Authors

MSMely Widia SukmaAAAbd. Wahid Rizaldi AkiliAHAri Hardianto

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Overview

This study demonstrates improved flavonoid extraction and antioxidant activity using natural deep eutectic solvents, indicating a sustainable extraction method.

Key Points

  • NADES11 exhibited the highest total flavonoid content, significantly outperforming ethanol extraction methods.
  • Under optimal extraction conditions of 97 min, 64 °C, and 1:25 solvent-to-material ratio, higher antioxidant activities were recorded.
  • Thirteen formulations of NADES were tested, with NADES11 consisting of lactic acid, citric acid, and glycerol yielding the best results.
  • The study employs response surface methodology and central composite design for systematic optimization of the extraction process.

Cite This Study

Sukma et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd11420https://doi.org/10.48048/tis.2025.11099
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Also Consider

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  1. 1Ultrasound-Assisted Deep Eutectic Solvent Extraction of Flavonoids from Cercis chinensis Seeds: Optimization, Kinetics and Antioxidant Activity2025 · 8 citations
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  3. 3Natural Deep Eutectic Solvents as Alternative Media for the Extraction of Phenolic Compounds from Crataegus monogyna2026
  4. 4Construction of Green System for Flavonoids from Dalbergia Pinnata (Lour.) Prain Based on NADES-UAE: Intelligent Optimization–Molecular Mechanism–Activity Verification2026 · 1 citations
  5. 5Optimization of Flavonoid Extraction and Tyrosinase Inhibitory Activity from <i>Rhodomyrtus tomentosa</i> Leaves Using NADES-Based Ultrasound-Assisted Extraction2026 · 1 citations