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March 7, 2026Tropical Journal of Natural Product ResearchOpen Access

Optimization of Flavonoid Extraction and Tyrosinase Inhibitory Activity from Rhodomyrtus tomentosa Leaves Using NADES-Based Ultrasound-Assisted Extraction

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Authors

AAAngelia AngeliaAAAnisa AgustinaUFUmi Fatimah

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Overview

Demonstrates optimized flavonoid extraction in Rhodomyrtus tomentosa, suggesting effective skin-lightening agents.

Key Points

  • This research seeks to enhance the extraction of flavonoids and evaluate their tyrosinase inhibitory activity from Rhodomyrtus tomentosa leaves.
  • Used ultrasound-assisted extraction with natural deep eutectic solvents (NADESs).
  • Evaluated various choline chloride-based NADESs for extraction efficiency.
  • Optimized extraction conditions using response surface methodology with Box-Behnken design.
  • Determined flavonoid content and tyrosinase inhibition spectrophotometrically.
  • Choline chloride-propylene glycol (1:1) was the most effective NADES.
  • Optimal conditions were 60 min extraction time, 20% water addition, and 0.05 g/mL solid-to-liquid ratio.
  • Achieved total flavonoid content of 14.3729 mg QE/g dried leaves and 83.56% tyrosinase inhibition.
  • Demonstrated high model accuracy with R² values of 0.9944 and 0.9998.

Cite This Study

Angelia et al. (2026) studied this question.

synapsesocial.com/papers/69abc0925af8044f7a4e93c8https://doi.org/10.26538/tjnpr/v10i2.10
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