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September 29, 2025Trends in Sciences

Acute Toxicity Evaluation of A Combined Extract (Mitragyna Speciosa and Lagerstroemia Speciosa) Leaves in Rats: Hematological, Biochemical and Histopathological Examinations

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Authors

JPJanejira PusarattanawongWRWarit RuanglertboonBBBoonyakorn Boonsri

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Overview

Animal study evaluates acute toxicity, revealing no significant changes in hematological and biochemical parameters.

Key Points

  • No signs of acute toxicity were observed in the behavioral, hematological, or biochemical assessments.
  • The combined extract of mitragyna speciosa and lagerstroemia speciosa showed normal ranges for all studied parameters.
  • HPLC techniques confirmed active compounds, ensuring accurate analysis of extracts for safety evaluation.
  • Histopathological examination confirmed tissue integrity in liver and kidneys, supporting low toxicity classification.

Cite This Study

Pusarattanawong et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd1142bhttps://doi.org/10.48048/tis.2026.10867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Toxicity assessment of <i>Mitragyna speciosa</i> leaf extracts using zebrafish ( <i>Danio rerio</i> ) embryos and analysis of their Q-TOF LCMS chemical profiles2026
  2. 2TOXICOLOGICAL PROFILE AND ANTINOCICEPTIVE ACTIVITY OF ETHANOLIC LEAF EXTRACT OF EREMOMASTAX SPECIOSA IN RODENTS: ENVIRONMENTAL-HEALTH AND SUSTAINABLE-USE IMPLICATIONS2026
  3. 3Safety Evaluation of the Aqueous Extract of the Mixture of <i>Persea americana</i> (Lauraceae), <i>Cymbopogon citratus</i> (Poaceae), Fruits of <i>Citrus medica</i> (Rutaceae), and Honey in Wistar Rat2025
  4. 4Evaluation of valoneic acid and the cytostasis properties of lagerstroemia speciosa ethanolic leaf extract on the accumulation of MPS in the complete blood count of the albino rats2024
  5. 5Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.2024 · 6 citations