What does this research mean for the field?

The ethanolic leaf extract of Eremomastax speciosa possesses substantial dose-dependent antinociceptive activity and low acute biochemical toxicity in rodents, though it may present haematological safety signals. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the safety and effectiveness of the ethanolic leaf extract of Eremomastax speciosa in rodents.

July 17, 2026Open Access

Toxicological Profile and Antinociceptive Activity of Ethanolic Leaf Extract of Eremomastax Speciosa in Rodents: Environmental-Health and Sustainable-Use Implications

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Authors

JAJoseph Akpan PWPaschal Wokota FUFrancis Udoh

Discussion

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Overview

Randomized trial evaluates antinociceptive effects and toxicity in rodents, indicating potential health benefits and safety for use in medicine.

Key Points

This study aims to evaluate the safety and effectiveness of the ethanolic leaf extract of Eremomastax speciosa in rodents.
Conducted phytochemical analysis to identify active compounds.
Assessed acute and repeated oral toxicity using Lorke’s procedure and various toxicity indices.
Evaluated antinociceptive activity through the acetic acid-induced writhing and hot-plate tests.
No mortality at 5,000 mg/kg, indicating an oral LD50 above this dose.
The extract reduced writhing by 70.4–93.8% with increased hot-plate latency at 200 mg/kg.
Observed lower packed cell volume and white-cell counts suggest potential haematological safety concerns.

Cite This Study

Akpan et al. (2026) studied this question.

synapsesocial.com/papers/6a59c733a58755010b472293 https://doi.org/10.83374/jesber.vol1no2.36

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July 17, 2026Open Access

Toxicological Profile and Antinociceptive Activity of Ethanolic Leaf Extract of Eremomastax Speciosa in Rodents: Environmental-Health and Sustainable-Use Implications

View Full Paper

Ask AI

Bookmark

Authors

JAJoseph Akpan PWPaschal Wokota FUFrancis Udoh

Discussion

Member takes

Overview

Randomized trial evaluates antinociceptive effects and toxicity in rodents, indicating potential health benefits and safety for use in medicine.

Key Points

This study aims to evaluate the safety and effectiveness of the ethanolic leaf extract of Eremomastax speciosa in rodents.
Conducted phytochemical analysis to identify active compounds.
Assessed acute and repeated oral toxicity using Lorke’s procedure and various toxicity indices.
Evaluated antinociceptive activity through the acetic acid-induced writhing and hot-plate tests.
No mortality at 5,000 mg/kg, indicating an oral LD50 above this dose.
The extract reduced writhing by 70.4–93.8% with increased hot-plate latency at 200 mg/kg.
Observed lower packed cell volume and white-cell counts suggest potential haematological safety concerns.

Cite This Study

Akpan et al. (2026) studied this question.

synapsesocial.com/papers/6a59c733a58755010b472293 https://doi.org/10.83374/jesber.vol1no2.36

View Full Paper

Ask AI

Bookmark