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October 2, 2025Pharmacognosy ResearchOpen Access

Medical Plants Aframomum melegueta and Xylopia aethiopica Show Low Toxicity in vitro and in vivo Highlighting their Potential for Therapeutic Applications

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Authors

EAEssimanam Rosalie AwessoKAKathrin ArndtsGKGnatoulma Katawa

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Overview

Original article evaluates toxicity of hydro-ethanolic extracts from Aframomum melegueta and Xylopia aethiopica, implying safety for therapeutic applications.

Key Points

  • The study revealed low toxicity of hydro-ethanolic extract fractions from Aframomum melegueta and Xylopia aethiopica.
  • Cytotoxicity testing showed cell death of less than 5%, indicating minimal harm to cells from the extracts.
  • Histological analysis displayed inflammatory cells in liver and kidney sections, suggesting a localized response.
  • Sub-acute toxicity tests demonstrated no significant changes in blood composition or biochemical parameters of rats.

Cite This Study

Awesso et al. (2025) studied this question.

synapsesocial.com/papers/68de79595b556a9128e1a403https://doi.org/10.5530/pres.20250030
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