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September 29, 2025Cancer MedicineOpen Access

Comprehensive Genomic Profiling in Advanced Non‐Small Cell Lung Cancer: A Real‐World Cohort Study in Finland

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Cohort study identified actionable genomic alterations in non-small cell lung cancer patients, suggesting targeted therapy improvements.

Actionable alterations were found in 45% of patients, enhancing potential treatment options.
KRAS G12C was the most common alteration at 18%, with only one-third of patients receiving targeted therapy.
The median tumour mutational burden was 5, and 31% of patients had a TMB greater than 10.
CGP aids treatment strategies but may face real-world application challenges due to therapy availability.

Hormalainen et al. (2025) studied this question.

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