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September 29, 2025Rheumatology (Bulgaria)Open Access

New Insights Into the Pathogenesis of Osteoarthritis

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Authors

IMIrina MomchevaVGV GonchevMVMikhail Yuryevich Valkov

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Overview

This report examines the multifactorial pathogenesis of osteoarthritis, highlighting epigenetic and genetic factors.

Key Points

  • The study reveals how genetic and epigenetic factors contribute to osteoarthritis development.
  • Research indicates that mechanisms like JAK/STAT signaling and mitochondrial dysfunction play critical roles in osteoarthritis.
  • Observational analysis highlights the significance of cellular responses and inflammation in osteoarthritis pathogenesis.
  • Understanding these mechanisms could lead to better management strategies for osteoarthritis in the future.

Cite This Study

Momcheva et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd11467https://doi.org/10.35465/33.1.2025.pp36-56
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Osteoarthritis: Epidemiology, Pathogenesis, and Treatment2026 · 7 citations
  2. 2Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations2013 · 1,106 citations
  3. 3Genetic and Epigenetic Insights into Osteoarthritis Pathogenesis; Spotlighting STAT3 and miR-452-3p as Illuminating Examples2024
  4. 4Osteoarthritis: Mechanisms and Therapeutic Advances2025 · 41 citations
  5. 5Critical Overview of Molecular Insights into Osteoarthritis and Therapeutic Targets: Cytokines, RANKL, MMPs, Adipokines and Phosphate Dysregulation2026