September 29, 2025Open Access

Genetic Polymorphisms of IL6-174G/C TNFα-308G/A and TNFα-238G/A and Risk to Pleural Tuberculosis in Venezuelan Patients

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Authors

ZAZaı̈da AraujoCentral University of Venezuela JWJacobus H. de WaardUniversidad de Especialidades Espíritu Santo MFMercedes Fernández‐MestreInstituto Venezolano de Investigaciones Científicas

Discussion

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Implication

This analysis identifies IL6 and TNFα polymorphisms as genetic markers for pleural tuberculosis in Venezuelan patients, suggesting increased susceptibility.

Key Points

Patients with pleural tuberculosis showed significantly increased frequencies of IL6-174G/C and TNFα polymorphisms compared to healthy controls.
Logistic regression analysis indicated strong associations of genetic polymorphisms with susceptibility to pleural tuberculosis.
This study involved 269 individuals, including 69 patients with pleural tuberculosis and 200 healthy controls.
Findings highlight the potential of cytokine gene polymorphisms as genetic biomarkers in tuberculosis susceptibility research.

Cite This Study

Araujo et al. (2025) studied this question.

synapsesocial.com/papers/68da58e0c1728099cfd11669 https://doi.org/10.20944/preprints202509.2198.v1

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Implication

This analysis identifies IL6 and TNFα polymorphisms as genetic markers for pleural tuberculosis in Venezuelan patients, suggesting increased susceptibility.

Genetic Polymorphisms of IL6-174G/C TNFα-308G/A and TNFα-238G/A and Risk to Pleural Tuberculosis in Venezuelan Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Genetic Polymorphisms of IL6-174G/C TNFα-308G/A and TNFα-238G/A and Risk to Pleural Tuberculosis in Venezuelan Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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