What question did this study set out to answer?

To evaluate and compare genotype distributions of specific cytokine gene polymorphisms between patients with pulmonary and extrapulmonary tuberculosis.

January 1, 2025Memórias do Instituto Oswaldo CruzOpen Access

Single nucleotide polymorphisms in IFN-gamma, TNF-alpha, IL-6, IL-10, and TGF-beta in pulmonary and extrapulmonary tuberculosis in the State of Ceará, northeastern Brazil

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Authors

RLRoberta dos Santos Silva LuizUniversidade Federal do Ceará TCThales Alves CampeloUniversidade Federal do Ceará CSCaroliny Soares SilvaUniversidade do Estado do Pará

Discussion

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Implication

Comparative study reveals distinct IL-6 polymorphism distributions in pulmonary versus extrapulmonary tuberculosis, indicating limited cytokine genetic influence on disease manifestation.

Key Points

To evaluate and compare genotype distributions of specific cytokine gene polymorphisms between patients with pulmonary and extrapulmonary tuberculosis.
Comparative genetic analysis evaluating 82 pulmonary tuberculosis (PTB) cases and 45 extrapulmonary tuberculosis (EPTB) cases.
Genotyping performed using sequence-specific primer polymerase chain reaction (PCR) for IFN-gamma +874 T > A, TNF-alpha -308 G > A, IL-6 -174 G > C, IL-10 -1082 A > G, and TGF-beta codons 10 and 25.
For IL-6 -174 G > C, the GG genotype predominated overall, with CG significantly more frequent in PTB and GG significantly more frequent in EPTB.
Genotype distributions for IFN-gamma +874 (AA most frequent), TNF-alpha -308 (GG predominated), IL-10 -1082 (AA predominated), and TGF-beta codons 10 and 25 showed no statistically significant differences between PTB and EPTB groups.

Cite This Study

Luiz et al. (2025) studied this question.

synapsesocial.com/papers/6aaf95d884c19a519ba60443 https://doi.org/10.1590/0074-02760240147

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Implication

Comparative study reveals distinct IL-6 polymorphism distributions in pulmonary versus extrapulmonary tuberculosis, indicating limited cytokine genetic influence on disease manifestation.

Single nucleotide polymorphisms in IFN-gamma, TNF-alpha, IL-6, IL-10, and TGF-beta in pulmonary and extrapulmonary tuberculosis in the State of Ceará, northeastern Brazil

Discussion

Member takes

Implication

Key Points

Cite This Study

Single nucleotide polymorphisms in IFN-gamma, TNF-alpha, IL-6, IL-10, and TGF-beta in pulmonary and extrapulmonary tuberculosis in the State of Ceará, northeastern Brazil

Discussion

Member takes

Implication

Key Points

Cite This Study

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