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September 29, 2025Acta Dermatovenerologica Alpina Pannonica et Adriatica

Toxic epidermal necrolysis: lessons from three fatal cases

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Authors

MDMarko DemenjUniversity of BelgradeVRVesna ReljićUniversity of BelgradeEMEmilija Manojlović-GačićUniversity of Belgrade

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Implication

Case analysis reveals comorbidities and treatment challenges in toxic epidermal necrolysis patients, suggesting high-risk factors.

Key Points

  • Mortality in toxic epidermal necrolysis is linked to comorbidities, which complicate the condition and treatment outcomes.
  • Among three fatal cases, treatment with low-dose IVIg was ineffective, resulting in multiorgan failure in one patient.
  • Misdiagnosis in toxic epidermal necrolysis can lead to fatal outcomes, as seen in the case mistaken for mycoplasma-induced rash.
  • Renal disease is highlighted as a significant risk factor influencing mortality rates in toxic epidermal necrolysis patients.

Cite This Study

Demenj et al. (2025) studied this question.

synapsesocial.com/papers/68da63b65b96be28fdab9d49https://doi.org/10.15570/actaapa.2025.27
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Toxic epidermal necrolysis‐like lupus2021 · 16 citations
  2. 2Balkan endemic nephropathy--current status and future perspectives2013 · 85 citations
  3. 3Mortality and risk factors on admission in toxic epidermal necrolysis: A cohort study of 59 patients2020 · 33 citations
  4. 4The clinical characteristics, putative drugs, and optimal management of 62 patients with stevens-johnson syndrome and/or toxic epidermal necrolysis: A retrospective observational study2022 · 12 citations