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August 26, 2025Open Access

Analysis of the clinical characteristics and prognostic influencing factors of toxic epidermal necrolysis: A report of 52 cases

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Authors

ZHZelin HuHBHuining BianHLHongmin Luo

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Overview

Retrospective analysis reveals high mortality in toxic epidermal necrolysis patients, indicating SCORTEN as a key prognostic factor.

Key Points

  • Toxic epidermal necrolysis shows high mortality, particularly in patients with sepsis and higher SCORTEN scores.
  • Among 52 observed cases, all deceased patients had sepsis, while 21.15% were linked to allopurinol as a suspected allergen.
  • Retrospective review of clinical data from 52 TEN patients admitted from January 2008 to January 2024 provided insights on risk factors.
  • The findings suggest that timely diagnosis of TEN is challenging, emphasizing the need for awareness of its serious implications.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68af620aad7bf08b1eae31afhttps://doi.org/10.21203/rs.3.rs-7263673/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In-hospital outcomes of SJS/TEN cases in a tertiary center: a 15-year cohort study2026
  2. 2Evaluation of the Factors Influencing Mortality in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Multicenter Study of 166 Patients2024 · 9 citations
  3. 3Incidence and Factors Associated With In-Hospital Mortality in Adult Patients With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Nationwide Thai Cohort2026
  4. 4P077 Toxic Epidermal Necrolysis-Optimal Management (TEN-OM): a retrospective cohort analysis from two centres2024
  5. 5Clinical features of Stevens — Johnson syndrome and toxic epidermal necrolysis: An observational cohort retrospective study2025