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Clinical features of Stevens — Johnson syndrome and toxic epidermal necrolysis: An observational cohort retrospective study

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Observational cohort study reveals etiology and mortality in patients with stevens johnson syndrome and toxic epidermal necrolysis.

Patients with toxic epidermal necrolysis had a mortality rate of 4%, with a SCORTEN score predicting higher risk.
Over 55% of cases were triggered by medications, particularly antibiotics and non-steroidal anti-inflammatory drugs.
Symptoms generally developed within the first week for toxic epidermal necrolysis and around the fourth week for stevens johnson syndrome.
A significant portion of patients did not have an identifiable trigger for their condition, highlighting diagnostic challenges.

Нуртдинова et al. (2025) studied this question.

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View Full Paper

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Authors

Observational cohort study reveals etiology and mortality in patients with stevens johnson syndrome and toxic epidermal necrolysis.

Patients with toxic epidermal necrolysis had a mortality rate of 4%, with a SCORTEN score predicting higher risk.
Over 55% of cases were triggered by medications, particularly antibiotics and non-steroidal anti-inflammatory drugs.
Symptoms generally developed within the first week for toxic epidermal necrolysis and around the fourth week for stevens johnson syndrome.
A significant portion of patients did not have an identifiable trigger for their condition, highlighting diagnostic challenges.

Нуртдинова et al. (2025) studied this question.

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