September 30, 2025Open Access
Symmetrical Dimethylarginine as the Central Antigenic Determinant of Anti-Smith Autoantibodies in Systemic Lupus Erythematosus
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Implication
Research identifies symmetrical dimethyl arginine as a key target for autoantibodies in systemic lupus erythematosus, highlighting their promiscuous nature.
Key Points
- Most anti-Sm IgGs in SLE patients target the sDMA residue, suggesting a common pathogenic mechanism.
- Approximately 90% of anti-Sm antibodies recognize sDMA residues regardless of the source peptide sequence.
- Cross-reactivity with various proteins indicates that this antibody response is highly promiscuous.
- Findings may link viral infections to autoimmunity in anti-Sm positive systemic lupus erythematosus patients.
Cite This Study
Vliet et al. (2025) studied this question.