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April 1, 1997Arthritis & Rheumatism

A major, novel systemic lupus erythematosus autoantibody class recognizes the E, F, and G Sm snRNP proteins as an E‐F‐G complex but not in their denatured states

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Implication

Does not support changes in SLE serologic testing; leaves open whether native E-F-G conformations drive pathogenicity.

Cite This Study

Brahms et al. (1997) studied this question.

synapsesocial.com/papers/6a8c44d20ca85c7e33df364e https://doi.org/10.1002/art.1780400412

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1The complete primary structure of the human snRNP E proteinOriginal Research · 1988 · 42 citations
2Autoantibody production against the U small nuclear ribonucleoprotein particle proteins E, F and G in patients with connective tissue diseasesOriginal Research · 1990 · 21 citations
3Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosusOriginal Research · 1979 · 1,194 citations
4Small nuclear RNA-associated proteins are immunologically related as revealed by mapping of autoimmune reactive B-cell epitopes.Original Research · 1989 · 73 citations