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September 30, 2025Open Access

Exome-wide association study in 54,698 south Asians identifies novel type 2 diabetes associations with RNF19A, HNF4A, and dissects role of coding variants in GP2 and CDKAL1

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Authors

SHSam HodgsonVBVan-Minh BuiMBMargherita Bigossi

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Overview

ExWAS shows novel associations with RNF19A and HNF4A in South Asian populations, suggesting new insights for T2D treatment.

Key Points

  • Novel associations with RNF19A and HNF4A were found, significantly improving our understanding of genetic risk in T2D among South Asians.
  • The protective variant in HNF4A demonstrated an odds ratio of 0.48 against T2D, highlighting its potential as a therapeutic target.
  • Meta-analysis indicated that plasma GP2 levels could serve as a biomarker for increased genetic risk of beta-cell deficiency related to T2D.
  • These findings emphasize the need for precision medicine tailored to South Asian populations who are disproportionately affected by T2D.

Cite This Study

Hodgson et al. (2025) studied this question.

synapsesocial.com/papers/68dc12c58a7d58c25ebb09cahttps://doi.org/10.1101/2025.09.24.25336527
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Also Consider

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