Key result
Genetic variants at ZFAND6, PRC1, and TMEM154 loci were significantly associated with type 2 diabetes, with the combined risk of 9 variants showing an OR of 1.91 (95% CI 1.18-3.08; p=0.008).
Why the study?
South Asians have a different manifestation of type 2 diabetes and a high cardiometabolic burden, requiring validation of recently identified GWAS loci in an endogamous North Indian population.
Are previously identified GWAS loci associated with Type 2 Diabetes in an endogamous North Indian population?
Case-Control (n=403)
Yes
Are previously identified GWAS loci associated with Type 2 Diabetes in an endogamous North Indian population?
Odds Ratio: 1.91 (95% CI 1.18–3.08)
p-value: p=0.008
The study confirms the association of ZFAND6, PRC1, and TMEM154 loci with type 2 diabetes in a North Indian population, extending the validity of these GWAS loci to South Asians.
No takes yet. Share an insight, caveat, or question.
Validation of three loci in this small North Indian cohort is hypothesis-generating; larger replication needed before broader applicability.
Walia et al. (2023) conducted a case-control in Type 2 diabetes (n=403). Genetic variants at 15 GWAS loci vs. Controls without type 2 diabetes was evaluated on Type 2 diabetes (OR 1.91, 95% CI 1.18-3.08, p=0.008). Genetic variants at ZFAND6, PRC1, and TMEM154 loci were significantly associated with type 2 diabetes, with the combined risk of 9 variants showing an OR of 1.91 (95% CI 1.18-3.08; p=0.008).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: