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September 30, 2025Deleted JournalOpen Access

Highly pathogenic avian influenza A H5N1 virus infection in an immunocompromised domestic cat

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Authors

CCChi ChenNanjing University of Finance and EconomicsANAkhila NaruUniversity of Illinois Urbana-ChampaignMRMareddy Vineetha ReddyUniversity of Illinois Urbana-Champaign

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Overview

A case report reveals acute H5N1 infection in an immunocompromised cat, suggesting urgent preventive strategies.

Key Points

  • The infection resulted in severe clinical signs, including fever and respiratory distress, leading to euthanasia.
  • Postmortem examination showed severe bronchointerstitial pneumonia and necrosis in multiple organs, highlighting the virus's lethality.
  • Whole-genome sequencing confirmed the virus's relation to currently circulating H5N1 strains, pointing to environmental transmission.
  • Clinicians need to be vigilant about potential H5N1 infections in cats exhibiting respiratory or neurological symptoms.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68dc12cc8a7d58c25ebb0e96https://doi.org/10.1128/asmcr.00134-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multisystemic manifestations of highly pathogenic avian influenza (H5N1) in a young domestic shorthair cat2025
  2. 2Clinical Course, Laboratory Findings, and Tissue Distribution of Highly Pathogenic Avian Influenza A(H5N1) Virus in a Naturally Infected Domestic Cat2026
  3. 3H5N1 Clade 2.3.4.4b Infections in Domestic Cats During an Avian Influenza Outbreak in Italy: Implications for One Health Surveillance2026
  4. 4Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 20232024 · 16 citations
  5. 5Companion animals and H5N1 highly pathogenic avian influenza: cause for concern?2025 · 4 citations