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July 1, 2025Journal of Feline Medicine and Surgery Open ReportsOpen Access

Multisystemic manifestations of highly pathogenic avian influenza (H5N1) in a young domestic shorthair cat

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Authors

KGKyle L GrangerCGChase GrossCFChad Frank

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Overview

Case report details severe respiratory distress and systemic disease in a cat, indicating high viral loads linked to environmental contamination.

Key Points

  • This case explores the manifestations of highly pathogenic avian influenza infection in a domestic shorthair cat.
  • Case summary of a domestic shorthair cat with clinical evaluations and advanced diagnostics.
  • Utilized real-time RT-PCR to confirm H5N1 in brain and lung tissues.
  • Post-mortem analysis included histopathologic examination and evaluation of other pathogens.
  • The cat exhibited severe respiratory distress and systemic disease, leading to euthanasia.
  • Real-time RT-PCR indicated high viral loads with pronounced neurotropism.
  • No other significant pathogens, such as rabies or feline calicivirus, were detected.

Cite This Study

Granger et al. (2025) studied this question.

synapsesocial.com/papers/69255726c0ce034ddc35a387https://doi.org/10.1177/20551169251376559
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Highly pathogenic avian influenza A H5N1 virus infection in an immunocompromised domestic cat2025 · 4 citations
  2. 2Clinical Course, Laboratory Findings, and Tissue Distribution of Highly Pathogenic Avian Influenza A(H5N1) Virus in a Naturally Infected Domestic Cat2026
  3. 3A Fatal A/H5N1 Avian Influenza Virus Infection in a Cat in Poland2023 · 21 citations
  4. 4Clinical and Laboratory Findings in Cats with Confirmed Avian Influenza A/H5N1 Virus Infection During the 2023 Outbreak in Poland: A Retrospective Case Series of 22 Cats2026 · 2 citations
  5. 5H5N1 Clade 2.3.4.4b Infections in Domestic Cats During an Avian Influenza Outbreak in Italy: Implications for One Health Surveillance2026